MUCOSAVE™FG NATURAL INGREDIENT WITH PREBIOTIC ACTIVITY TO COUNTERACT GATROESOPHAGEAL REFLUX DISEASE AND IMPROVE THE QUALITY OF LIFE.

Gastrointestinal discomfort (GD) is a common disorder that affects 40% of the adult population worldwide1.

In recent years, significant lifestyle changes caused an increase in GERD incidence. Besides the typical GERD symptoms like regurgitation and heartburn, impairment of QoL includes disturbed sleep, body pain, anxiety, and unsatisfactory sex life2. The reflux episodes can occur in daytime but nocturnal symptoms have an important influence on QoL and are associated with complications of GERD.

Natural ingredients represent an interesting option for the management of gastrointestinal disorders3.

BIONAP has developed MUCOSAVE™FG, a blend of two herbal extracts containing polysaccharides of prickle pear cladodes (Opuntia ficus indica (L.)) and biophenols of olive leaves (Olea europaea (L.)). MUCOSAVE™FG is a unique combination specifically created for mucosal support and to counteract the main symptoms caused by gastrointestinal disorders.

MUCOSAVE™FG antiulcerogenic and gastroprotective properties shown in pre-clinical evaluations4-5-6, have beneficial effects in people suffering from GD. Indeed, results from a randomized double-blind placebo-controlled clinical trial recently published suggest that MUCOSAVE™FG supplementation counteracts GERD symptoms and has a positive impact on the quality of life of people suffering of GD8

Moreover, In vitro test demonstrated that MUCOSAVE™FG possesses significant bifidogenic activity comparable to that exerted by inulin, in addition, recent preliminary clinical data support the prebiotic activity of MUCOSAVE™FG, which is able to modulate the gut microbiota either by direct growth stimulation of beneficial gut bacteria and through antimicrobial effects  on bacterial pathogens thus balancing the gut microbiota in people suffering from GD. 

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    1. Sperber, A. D. et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. Gastroenterology 160, 99-114.e3 (2021).
    2. Alecci, U., Bonina, F., Bonina, A. et al. (2016). Efficacy and safety of a natural remedy for the treatment of gastroesophageal reflux: a double-blinded randomized-controlled study. Evid Based Complement Alternat Med. 2016: 1-8. doi:10.1155/2016/2581461
    3. Pino, A., De Angelis, M., Chieppa, M. et al. (2020). Gut Microbiota, Probiotics And Colorectal Cancer: A Tight Relation. WCRJ. 7: e1456, doi.org/10.32113/wcrj_20201_1456.
    4. Di Lorenzo, F., Silipo, A., Molinaro, A. et al. (2017). The polysaccharide and low molecular weight components of Opuntia ficus indica cladodes: Structure and skin repairing properties. Carbohydr. Polym. 157:128-136. doi: 10.1016/j.carbpol.2016.09.073
    5. Galati, E., Monforte, M., Tripodo, M., et al. (2001). Antiulcer activity of O. ficus-indica (L.) Mill. (Cactaceae): ultrastructural study. J. Ethnopharmacol. 76 1-9. doi:10.1016/s0378-8741(01)00196-9
    6. Galati, E. M., Pergolizzi, S., Miceli, N., Monforte, M. T. & Tripodo, M. M. Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes. J. Ethnopharmacol. 83, 229–233 (2002)
    7. Malfa, G. A. et al. A standardized extract of Opuntia ficus-indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort: A double-blinded randomized-controlled study. Phyther. Res. 1–13 (2021) doi:10.1002/ptr.7074
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